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Hyaluronidase
Hyaluronidase is an enzyme that breaks down hyaluronic acid. With the increasing popularity of hyaluronic acid filler, hyaluronidase has become an essential drug for the correction of complications and unsatisfactory results after filler injection.
In order for hyaluronidase to dissolve a hyaluronic acid filler, it must interact with its binding sites within the hyaluronic acid.
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If the filler is placed subcutaneously, injection of hyaluronidase into the filler itself may help, but if the filler is placed within a blood vessel, it is sufficient to inject hyaluronidase in the vicinity of the vessel, instead of into the filler itself.
It is important for patients to be aware of the risks, allergic reactions are a common side effect of hyaluronidase.
Most allergic reactions to hyaluronidase are local, but systemic reactions may occur in infrequent cases. Since most allergic responses to hyaluronidase are immediate hypersensitivity reactions, skin patch tests are recommended before use.
However, some patients experience delayed allergic reactions, which skin tests may not predict.